Mathematical Modeling Insights into Improving CAR T cell Therapy for Solid Tumors: Antigen Heterogeneity and Bystander Effects

no code implementations • 10 Jul 2023 • Erdi Kara, T. L. Jackson, Chartese Jones, Reginald L. McGee II, Rockford Sison

A critical question for solving the heterogeneity problem is whether CAR T therapy induces bystander effects, such as antigen spreading.