Optimizing Lymphocyte Detection in Breast Cancer Whole Slide Imaging through Data-Centric Strategies

no code implementations • 22 May 2024 • Amine Marzouki, Zhuxian Guo, Qinghe Zeng, Camille Kurtz, Nicolas Loménie

Efficient and precise quantification of lymphocytes in histopathology slides is imperative for the characterization of the tumor microenvironment and immunotherapy response insights.

Regression-based Deep-Learning predicts molecular biomarkers from pathology slides

1 code implementation • 11 Apr 2023 • Omar S. M. El Nahhas, Chiara M. L. Loeffler, Zunamys I. Carrero, Marko van Treeck, Fiona R. Kolbinger, Katherine J. Hewitt, Hannah S. Muti, Mara Graziani, Qinghe Zeng, Julien Calderaro, Nadina Ortiz-Brüchle, Tanwei Yuan, Michael Hoffmeister, Hermann Brenner, Alexander Brobeil, Jorge S. Reis-Filho, Jakob Nikolas Kather

We tested our method for multiple clinically and biologically relevant biomarkers: homologous repair deficiency (HRD) score, a clinically used pan-cancer biomarker, as well as markers of key biological processes in the tumor microenvironment.

Classification regression