no code implementations • 9 Nov 2023 • Terence R. Johnson, Philip E. Bourne
Biological data in digital form has become a, if not the, driving force behind innovations in biology, medicine, and the environment.
no code implementations • 23 Nov 2021 • Tian Cai, Li Xie, Muge Chen, Yang Liu, Di He, Shuo Zhang, Cameron Mura, Philip E. Bourne, Lei Xie
Advances in biomedicine are largely fueled by exploring uncharted territories of human biology.
no code implementations • 22 Jun 2021 • Zheng Zhao, Philip E. Bourne
Finally, we provide a brief perspective on future design strategies for RCKIs, including those that target proteins other than kinases.
no code implementations • 27 Apr 2021 • Zheng Zhao, Philip E. Bourne
Thus, obtaining the desired selectivity, given the whole human kinome, is a fundamental task during early-stage drug discovery.
no code implementations • 24 Apr 2021 • Cameron Mura, Saskia Preissner, Robert Preissner, Philip E. Bourne
We consider the recent surge of information on the potential benefits of acid-suppression drugs in the context of COVID-19, with an eye on the variability (and confusion) across the reported findings--at least as regards the popular antacid famotidine.
no code implementations • 1 May 2019 • Sean Mullane, Ruoyan Chen, Sri Vaishnavi Vemulapalli, Eli J. Draizen, Ke Wang, Cameron Mura, Philip E. Bourne
The biological function of a protein stems from its 3-dimensional structure, which is thermodynamically determined by the energetics of interatomic forces between its amino acid building blocks (the order of amino acids, known as the sequence, defines a protein).
no code implementations • 13 Jul 2018 • Philip E. Bourne
This is an article submitted to the Ten Simple Rules series of professional development articles published by PLOS Computational Biology.