no code implementations • 18 Jun 2019 • Renaud Dessalles, Yunbei Pan, Mingtao Xia, Davide Maestrini, Maria R. D'Orsogna, Tom Chou
Using a mean-field approximation to the solution of a regulated birth-death-immigration model and a modification arising from sampling, we systematically quantify how TCR-dependent heterogeneities in immigration and proliferation rates affect the shape of clone abundance distributions (the number of different clones that are represented by a specific number of cells, or "clone counts").
no code implementations • 8 May 2018 • Bhaven Mistry, Maria R. D'Orsogna, Nicholas E. Webb, Benhur Lee, Tom Chou
The early steps of membrane fusion and viral capsid entry are mediated by adsorption to the cell surface, and receptor and coreceptor binding.
