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Optimal control of ribosome population for gene expression under periodic nutrient intake
Using biophysical parameter values, we find that optimal control solutions lead to both control mechanisms and the ribosome population switching between periods of feeding and fasting, suggesting that the intense regulation of ribosome population observed in experiments allows to maximize and maintain protein production.
An equilibrium model for ribosome competition
The number of ribosomes in a cell is considered as limiting, and gene expression is thus largely determined by their cellular concentration.
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