Search Results for author: Kevin De Haan

Found 11 papers, 0 papers with code

Virtual histological staining of unlabeled autopsy tissue

no code implementations2 Aug 2023 Yuzhu Li, Nir Pillar, Jingxi Li, Tairan Liu, Di wu, Songyu Sun, Guangdong Ma, Kevin De Haan, Luzhe Huang, Sepehr Hamidi, Anatoly Urisman, Tal Keidar Haran, William Dean Wallace, Jonathan E. Zuckerman, Aydogan Ozcan

Histological examination is a crucial step in an autopsy; however, the traditional histochemical staining of post-mortem samples faces multiple challenges, including the inferior staining quality due to autolysis caused by delayed fixation of cadaver tissue, as well as the resource-intensive nature of chemical staining procedures covering large tissue areas, which demand substantial labor, cost, and time.

Image Registration

Virtual stain transfer in histology via cascaded deep neural networks

no code implementations14 Jul 2022 Xilin Yang, Bijie Bai, Yijie Zhang, Yuzhu Li, Kevin De Haan, Tairan Liu, Aydogan Ozcan

Unlike a single neural network structure which only takes one stain type as input to digitally output images of another stain type, C-DNN first uses virtual staining to transform autofluorescence microscopy images into H&E and then performs stain transfer from H&E to the domain of the other stain in a cascaded manner.

Virtual staining of defocused autofluorescence images of unlabeled tissue using deep neural networks

no code implementations6 Jul 2022 Yijie Zhang, Luzhe Huang, Tairan Liu, Keyi Cheng, Kevin De Haan, Yuzhu Li, Bijie Bai, Aydogan Ozcan

Here, we introduce a fast virtual staining framework that can stain defocused autofluorescence images of unlabeled tissue, achieving equivalent performance to virtual staining of in-focus label-free images, also saving significant imaging time by lowering the microscope's autofocusing precision.

Collaborative Inference

Label-free virtual HER2 immunohistochemical staining of breast tissue using deep learning

no code implementations8 Dec 2021 Bijie Bai, Hongda Wang, Yuzhu Li, Kevin De Haan, Francesco Colonnese, Yujie Wan, Jingyi Zuo, Ngan B. Doan, Xiaoran Zhang, Yijie Zhang, Jingxi Li, Wenjie Dong, Morgan Angus Darrow, Elham Kamangar, Han Sung Lee, Yair Rivenson, Aydogan Ozcan

The immunohistochemical (IHC) staining of the human epidermal growth factor receptor 2 (HER2) biomarker is widely practiced in breast tissue analysis, preclinical studies and diagnostic decisions, guiding cancer treatment and investigation of pathogenesis.

Generative Adversarial Network whole slide images

Deep learning-based transformation of the H&E stain into special stains

no code implementations20 Aug 2020 Kevin de Haan, Yijie Zhang, Jonathan E. Zuckerman, Tairan Liu, Anthony E. Sisk, Miguel F. P. Diaz, Kuang-Yu Jen, Alexander Nobori, Sofia Liou, Sarah Zhang, Rana Riahi, Yair Rivenson, W. Dean Wallace, Aydogan Ozcan

Based on evaluation by three renal pathologists, followed by adjudication by a fourth renal pathologist, we show that the generation of virtual special stains from existing H&E images improves the diagnosis in several non-neoplastic kidney diseases sampled from 58 unique subjects.

Deep learning-based holographic polarization microscopy

no code implementations1 Jul 2020 Tairan Liu, Kevin de Haan, Bijie Bai, Yair Rivenson, Yi Luo, Hongda Wang, David Karalli, Hongxiang Fu, Yibo Zhang, John FitzGerald, Aydogan Ozcan

Our analysis shows that a trained deep neural network can extract the birefringence information using both the sample specific morphological features as well as the holographic amplitude and phase distribution.

Medical Diagnosis

Digital synthesis of histological stains using micro-structured and multiplexed virtual staining of label-free tissue

no code implementations20 Jan 2020 Yijie Zhang, Kevin De Haan, Yair Rivenson, Jingxi Li, Apostolos Delis, Aydogan Ozcan

This approach uses a single deep neural network that receives two different sources of information at its input: (1) autofluorescence images of the label-free tissue sample, and (2) a digital staining matrix which represents the desired microscopic map of different stains to be virtually generated at the same tissue section.

Deep learning-based color holographic microscopy

no code implementations15 Jul 2019 Tairan Liu, Zhensong Wei, Yair Rivenson, Kevin De Haan, Yibo Zhang, Yichen Wu, Aydogan Ozcan

We report a framework based on a generative adversarial network (GAN) that performs high-fidelity color image reconstruction using a single hologram of a sample that is illuminated simultaneously by light at three different wavelengths.

Generative Adversarial Network Image Reconstruction

Resolution enhancement in scanning electron microscopy using deep learning

no code implementations30 Jan 2019 Kevin de Haan, Zachary S. Ballard, Yair Rivenson, Yichen Wu, Aydogan Ozcan

We report resolution enhancement in scanning electron microscopy (SEM) images using a generative adversarial network.

Generative Adversarial Network Super-Resolution

Cross-modality deep learning brings bright-field microscopy contrast to holography

no code implementations17 Nov 2018 Yichen Wu, Yilin Luo, Gunvant Chaudhari, Yair Rivenson, Ayfer Calis, Kevin De Haan, Aydogan Ozcan

Deep learning brings bright-field microscopy contrast to holographic images of a sample volume, bridging the volumetric imaging capability of holography with the speckle- and artifact-free image contrast of bright-field incoherent microscopy.

Deep learning-based super-resolution in coherent imaging systems

no code implementations15 Oct 2018 Tairan Liu, Kevin De Haan, Yair Rivenson, Zhensong Wei, Xin Zeng, Yibo Zhang, Aydogan Ozcan

We present a deep learning framework based on a generative adversarial network (GAN) to perform super-resolution in coherent imaging systems.

Generative Adversarial Network Image Reconstruction +1

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