1 code implementation • 1 Jan 2022 • Hongsong Feng, Kaifu Gao, Dong Chen, Alfred J Robison, Edmund Ellsworth, Guo-Wei Wei
Cocaine dependence is neurological and involves many interacting proteins in the interactome.
1 code implementation • 17 Sep 2021 • Kaifu Gao, Dong Chen, Alfred J Robison, Guo-Wei Wei
Cocaine addiction accounts for a large portion of substance use disorders and threatens millions of lives worldwide.
no code implementations • 14 Mar 2021 • Rui Wang, Jiahui Chen, Kaifu Gao, Guo-Wei Wei
We further unveil that mutation N501Y involved in United Kingdom (UK), South Africa, and Brazil variants may moderately weaken the binding between the RBD and many known antibodies, while mutations E484K and K417N found in South Africa and Brazilian variants can potentially disrupt the binding between the RDB and many known antibodies.
no code implementations • 1 Feb 2021 • Kaifu Gao, Rui Wang, Jiahui Chen, Limei Cheng, Jaclyn Frishcosy, Yuta Huzumi, Yuchi Qiu, Tom Schluckbier, Guo-Wei Wei
To provide the reader a quick update about the status of molecular modeling, simulation, and prediction of SARS-CoV-2, we present a comprehensive and systematic methodology-centered narrative in the nick of time.
no code implementations • 13 Oct 2020 • Jiahui Chen, Kaifu Gao, Rui Wang, GuoWei Wei
This discovery implies the vulnerability of current vaccines and antibody drugs to new mutations.
no code implementations • 24 Jul 2020 • Rui Wang, Jiahui Chen, Kaifu Gao, Yuta Hozumi, Changchuan Yin, Guo-Wei Wei
Using genotyping, sequence-alignment, time-evolution, $k$-means clustering, protein-folding stability, algebraic topology, and network theory, we reveal that the US SARS-CoV-2 has four substrains and five top US SARS-CoV-2 mutations were first detected in China (2 cases), Singapore (2 cases), and the United Kingdom (1 case).
no code implementations • 28 May 2020 • Kaifu Gao, Duc D. Nguyen, Meihua Tu, Guo-Wei Wei
Current drug discovery is expensive and time-consuming.
Biomolecules Quantitative Methods