Topological Data Analysis of Spatial Patterning in Heterogeneous Cell Populations: Clustering and Sorting with Varying Cell-Cell Adhesion

no code implementations • 28 Dec 2022 • Dhananjay Bhaskar, William Y. Zhang, Alexandria Volkening, Björn Sandstede, Ian Y. Wong

We further demonstrate that persistence images can be normalized to improve classification for simulations with varying cell numbers due to proliferation.

Classification Dimensionality Reduction +2

Mechanobiology of Collective Cell Migration in 3D Microenvironments

no code implementations • 6 Feb 2022 • Alex M. Hruska, Haiqian Yang, Susan E. Leggett, Ming Guo, Ian Y. Wong

First, we review the biology of collective cell migration.

Topological Data Analysis of Collective and Individual Epithelial Cells using Persistent Homology of Loops

no code implementations • 22 Mar 2020 • Dhananjay Bhaskar, William Y. Zhang, Ian Y. Wong

Instead, topological data analysis (TDA) determines the stability of spatial connectivity at varying length scales (i. e. persistent homology) and can compare different particle configurations based on the "cost" of reorganizing one configuration into another.

Topological Data Analysis