no code implementations • 9 Apr 2021 • Zachary Wu, Kadina E. Johnston, Frances H. Arnold, Kevin K. Yang
Protein engineering seeks to identify protein sequences with optimized properties.
no code implementations • 19 Feb 2019 • Zachary Wu, S. B. Jennifer Kan, Russell D. Lewis, Bruce J. Wittmann, Frances H. Arnold
To reduce experimental effort associated with directed protein evolution and to explore the sequence space encoded by mutating multiple positions simultaneously, we incorporate machine learning in the directed evolution workflow.
Biomolecules
no code implementations • 27 Nov 2018 • Kevin K. Yang, Zachary Wu, Frances H. Arnold
Machine learning (ML)-guided directed evolution is a new paradigm for biological design that enables optimization of complex functions.