Search Results for author: Douglas Pires

Found 3 papers, 0 papers with code

Large scale paired antibody language models

no code implementations26 Mar 2024 Henry Kenlay, Frédéric A. Dreyer, Aleksandr Kovaltsuk, Dom Miketa, Douglas Pires, Charlotte M. Deane

Antibodies are proteins produced by the immune system that can identify and neutralise a wide variety of antigens with high specificity and affinity, and constitute the most successful class of biotherapeutics.

Specificity

Automating reward function configuration for drug design

no code implementations15 Dec 2023 Marius Urbonas, Temitope Ajileye, Paul Gainer, Douglas Pires

We show that our algorithm yields reward functions that outperform the predictive accuracy of human-defined functions, achieving an improvement of up to 0. 4 in Spearman's correlation against a ground truth evaluation function that encodes the target drug profile for that project.

Drug Discovery

Quantifying machine learning-induced overdiagnosis in sepsis

no code implementations3 Jul 2021 Anna Fedyukova, Douglas Pires, Daniel Capurro

The proliferation of early diagnostic technologies, including self-monitoring systems and wearables, coupled with the application of these technologies on large segments of healthy populations may significantly aggravate the problem of overdiagnosis.

BIG-bench Machine Learning Management

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