Learning-Based Image Registration With Meta-Regularization

We introduce a meta-regularization framework for learning-based image registration. Current learning-based image registration methods use high-resolution architectures such as U-Nets to produce spatial transformations, and impose simple and explicit regularization on the output of the network to ensure that the estimated displacements are smooth. While this approach works well on small deformations, it has been known to struggle when the deformations are large. Our method uses a more advanced form of meta-regularization to increase the generalization ability of learned registration models. We motivate our approach based on Reproducing Kernel Hilbert Space (RKHS) theory, and approximate that framework via a meta-regularization convolutional layer with radially symmetric, positive semi-definite filters that inherent its regularization properties. We then provide a method to learn such regularization filters while also learning to register. Our experiments on synthetic and real datasets as well as ablation analysis show that our method can improve anatomical correspondence compared to competing methods, and reduce the percentage of folding and tear in the large deformation setting, reflecting better regularization and model generalization.