no code implementations • 26 Sep 2023 • Andreas Haghofer, Eda Parlak, Alexander Bartel, Taryn A. Donovan, Charles-Antoine Assenmacher, Pompei Bolfa, Michael J. Dark, Andrea Fuchs-Baumgartinger, Andrea Klang, Kathrin Jäger, Robert Klopfleisch, Sophie Merz, Barbara Richter, F. Yvonne Schulman, Hannah Janout, Jonathan Ganz, Josef Scharinger, Marc Aubreville, Stephan M. Winkler, Matti Kiupel, Christof A. Bertram
We assessed the following nuclear evaluation methods for measurement accuracy, reproducibility, and prognostic utility: 1) anisokaryosis (karyomegaly) estimates by 11 pathologists; 2) gold standard manual morphometry of at least 100 nuclei; 3) practicable manual morphometry with stratified sampling of 12 nuclei by 9 pathologists; and 4) automated morphometry using a deep learning-based segmentation algorithm.
no code implementations • 4 Dec 2020 • Frauke Wilm, Christof A. Bertram, Christian Marzahl, Alexander Bartel, Taryn A. Donovan, Charles-Antoine Assenmacher, Kathrin Becker, Mark Bennett, Sarah Corner, Brieuc Cossic, Daniela Denk, Martina Dettwiler, Beatriz Garcia Gonzalez, Corinne Gurtner, Annika Lehmbecker, Sophie Merz, Stephanie Plog, Anja Schmidt, Rebecca C. Smedley, Marco Tecilla, Tuddow Thaiwong, Katharina Breininger, Matti Kiupel, Andreas Maier, Robert Klopfleisch, Marc Aubreville
Density of mitotic figures in histologic sections is a prognostically relevant characteristic for many tumours.
1 code implementation • 13 Apr 2020 • Christian Marzahl, Christof A. Bertram, Marc Aubreville, Anne Petrick, Kristina Weiler, Agnes C. Gläsel, Marco Fragoso, Sophie Merz, Florian Bartenschlager, Judith Hoppe, Alina Langenhagen, Anne Jasensky, Jörn Voigt, Robert Klopfleisch, Andreas Maier
However, a significant percentage of the deliberately introduced false labels was not identified by the experts.
Human-Computer Interaction Image and Video Processing
1 code implementation • 12 Feb 2019 • Marc Aubreville, Christof A. Bertram, Christian Marzahl, Corinne Gurtner, Martina Dettwiler, Anja Schmidt, Florian Bartenschlager, Sophie Merz, Marco Fragoso, Olivia Kershaw, Robert Klopfleisch, Andreas Maier
Manual count of mitotic figures, which is determined in the tumor region with the highest mitotic activity, is a key parameter of most tumor grading schemes.