Finding steady-state solutions for ODE systems of zero, first and homogeneous second-order chemical reactions is NP-hard

10 Apr 2018 Reis Marcelo S.

In the context of modeling of cell signaling pathways, a relevant step is finding steady-state solutions for ODE systems that describe the kinetics of a set of chemical reactions, especially sets composed of zero, first, and second-order reactions. To compute a steady-state solution, one must set the left-hand side of each ODE as zero, hence obtaining a system of non-negative, quadratic polynomial equations... (read more)

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  • COMPUTATIONAL COMPLEXITY

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